39 Results for "

Uncaria rhynchophylla (Miq.) Miq. ex Havil.

" in MedChemExpress (MCE) Product Catalog:
Products (39)

39 Results for "Uncaria rhynchophylla (Miq.) Miq. ex Havil." in MCE Product Catalog:

6
Esculetin
Esculetin
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6 Publications Verification
Cat. No.: HY-N0284
CAS No.: 305-01-1
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

PI3K Akt

Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities .
6
Corynoxeine
Corynoxeine
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6 Publications Verification
Cat. No.: HY-N0590
CAS No.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
3
Corynoxine
Corynoxine
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3 Cited Publications
Cat. No.: HY-N0901
CAS No.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
2
Rhynchophylline
Rhynchophylline
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2 Cited Publications
Cat. No.: HY-N0387
CAS No.: 76-66-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Other Diseases Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

NF-κB

Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .
2
Fraxetin
Fraxetin
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2 Cited Publications
Cat. No.: HY-N0580
CAS No.: 574-84-5
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bacterial

Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell apoptosis .
2
Hirsuteine
Hirsuteine
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2 Cited Publications
Cat. No.: HY-N2197
CAS No.: 35467-43-7
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Neurological Disease Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

nAChR

Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
1
Hirsutine
Hirsutine
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1 Cited Publications
Cat. No.: HY-N2193
CAS No.: 7729-23-9
Category:  

Infection Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

Flavivirus Dengue Virus Apoptosis

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
Mitraphylline
Mitraphylline
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Cat. No.: HY-N6946
CAS No.: 509-80-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo .
Globulol
Globulol
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Cat. No.: HY-N8389
CAS No.: 489-41-8
Category:  

Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill.

Target:  

Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR

Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .
Asarinin
Asarinin
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Cat. No.: HY-N0701A
CAS No.: 133-05-1
Category:  

Asarum sieboldii Miq. Lignans Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Cancer

Target:  

Others

Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb .
Fraxetin (Standard)
Fraxetin (Standard)
0 Images
Cat. No.: HY-N0580R
CAS No.: 574-84-5
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Phenylpropanoids Plants

Target:  

Reference Standards Apoptosis

Fraxetin (Standard) is the analytical standard of Fraxetin. This product is intended for research and analytical applications. Fraxetin is isolated from Fraxinus rhynchophylla Hance. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis .
Isopteropodine
Isopteropodine
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Cat. No.: HY-N4157
CAS No.: 5171-37-9
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants

Target:  

mAChR 5-HT Receptor Bacterial

Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .
Esculetin (Standard)
Esculetin (Standard)
0 Images
Cat. No.: HY-N0284R
CAS No.: 305-01-1
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Phenols Polyphenols Phenylpropanoids Plants

Target:  

Reference Standards PI3K Akt

Esculetin (Standard) is the analytical standard of Esculetin. This product is intended for research and analytical applications. Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities .
9-Methoxyaristolactam I
9-Methoxyaristolactam I
0 Images
Cat. No.: HY-N11529
CAS No.: 133462-30-3
Category:  

Asarum sieboldii Miq. Alkaloids Pyrrole Alkaloids Plants Aristolochiaceae

Target:  

Others

9-Methoxyaristolactam I is a natural product that can be isolated from the roots of Asarum sieboldii Miq. var. Seoulense Nakai .
MIQ-N-succinate
MIQ-N-succinate
0 Images
Cat. No.: HY-155442
CAS No.: 1511896-15-3
Target:  

Biochemical Assay Reagents

Research Areas:  

Inflammation/Immunology

MIQ-N-succinate is a hapten with a four-carbon chain. MIQ-N-succinate consist of MIQ and succinic anhydride. MIQ-N-succinate has a carboxylic acid end group to attach to the lysine residues on the carrier proteins .
Uncargenin C
Uncargenin C
0 Images
Cat. No.: HY-N1112
CAS No.: 152243-70-4
Category:  

Triterpenes Staphyleaceae Terpenoids Plants Turpinia arguta (Lindl.) Seem.

Target:  

Others

Uncargenin C is a triterpenoid, which can be isolated from Uncaria rhychophyllo Miq. Jacks. The intermediate of Uncargenin C has anti-leukemia activity, but not itself .
Uncarine F
Uncarine F
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Cat. No.: HY-N16467
CAS No.: 14019-66-0
Synonyms: Speciofiline
Category:  

Alkaloids Oxindole Alkaloids Rubiaceae Plants Mitragyna parvifolia (Roxb.) Korth.

Target:  

Others

Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .
Calyciphylline A
Calyciphylline A
0 Images
Cat. No.: HY-N3525
CAS No.: 596799-30-3
Category:  

Alkaloids Other Alkaloids Plants Daphniphyllum macropodum Miq.

Target:  

Others

Calyciphylline A is a Alkaloids product that can be isolated from the branches of Daphniphyllum macropodum Miq. .
Daphnilongeridine
Daphnilongeridine
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Cat. No.: HY-N3684
CAS No.: 922522-15-4
Category:  

Alkaloids Plants Daphniphyllum macropodum Miq.

Target:  

Others

Daphnilongeridine is a Alkaloids product that can be isolated from the branches of Daphniphyllum macropodum Miq. .
Assay Types